Lives listing with initial: O
- Osborne, Mary Godolphin, duchess of Leeds [née Godolphin] (born 1723–died 1764), English aristocrat
- Osborne, Peregrine, 2nd duke of Leeds (born 1659–died 1729), English naval officer
- Osborne, Thomas, 1st duke of Leeds (born 1632–died 1712), English politician, member of Parliament
- Osgood, Joshua Bailey (born 1753–died 1791), American merchant, landowner, politician
- Ossun, Pierre Paul d’, marquis d’Ossun (born 1713–died 1788), French diplomat
- Ostenaco, Warrior (born c. 1703–died 1780), Native American (Cherokee) tribal leader, warrior
- Osterchamp, Gottfried Caspar (died 1719), Austrian physician
- Ostervald, Samuel (born 1692–died 1769), Swiss politician, legal author
- Osterwald, Frédéric Samuel (born 1713–died 1795), Swiss publisher, politician
- Oswald, Eleazer (born 1755–died 1795), American [unknown occupation]
- Oswald, Reverend Doctor James (born 1703–died 1793), Scottish churchman, Presbyterian, theologian
- Oswald of Dunnikier, James (born 1715–died 1769), Scottish politician, member of Parliament, lawyer, civil servant
- others (appears in EE 1730–1789), [unknown nationality & occupation]
- Otis, Harrison Gray (born 1765–died 1848), American [unknown occupation]
- Otis, James (born 1725–died 1783), American [unknown occupation]
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