Lives listing with initial: O
- Orléans, Louis Philippe Joseph d’, duc d’Orléans (born 1747–died 1793), French aristocrat, politician, revolutionary
- Orléans de Rothelin, Charles d’ (born 1691–died 1744), French churchman, scholar, academician, academic
- Orlov, Count Grigory Grigoryevich (born 1734–died 1783), Russian courtier, army officer, government minister
- Ormesson de Noiseau, Anne Louis François de Paule Lefevre d' (born 1753–died 1794), French librarian, politician
- Ormoy, Charlotte d’ [née Chaumet] (born c. 1732–died 1791), French educationalist, novelist, moralist
- Orne, Azor (born 1731–died 1796), American [unknown occupation]
- Orr, Benjamin Grayson (born 1768–died 1822), American [unknown occupation]
- Orry, Philibert, comte de Vignory (born 1689–died 1747), French government minister
- Orsi, marchese Giovan Gioseffo (born 1652–died 1733), Italian poet, literary critic
- Ortolani, F. (flourished c. 1747), Italian [unknown occupation]
- Osbaldeston, Reverend Richard, bishop of London (born 1691–died 1764), English churchman, bishop
- Osborn, Mr — (flourished 1750–1775), English [unknown occupation]
- Osborne, Francis, 5th duke of Leeds (born 1751–died 1799), English aristocrat, government minister, politician, member of Parliament
- Osborne, Henry (born 1751–died 1800), Irish [unknown occupation]
- Osborne, John (died 1791), Caribbean merchant
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