Lives listing with initial: O
- Otis, Joseph (born 1726–died 1809), American [unknown occupation]
- Otis, Samuel Allyne (born 1740–died 1814), American merchant, politician
- Otto, Louis Guillaume (born c. 1753–died 1817), French politician, diplomat
- Otway, Thomas (born 1652–died 1685), English author, playwright, poet
- Oudart, Nicholas (died 1681), Belgian physician, civil servant, private secretary, diplomat, academician
- Oughton, Sir James Adolphus Dickenson (born 1719–died 1780), English army officer, antiquarian
- Ougspurger, Karl Ludwig (born 1720–died 1795), Swiss soldier, army officer, politician
- Ouville, Pierre François Paul Berny d’ (died 1783), French lawyer, civil servant
- Owen, Captain (flourished c. 1717), [unknown nationality & occupation]
- Owen, Edward (died 1706), English hatter, politician, tradesman
- Owen, Sir Hugh, baronet (born 1645–died 1699), Welsh aristocrat, politician, member of Parliament
- Owen, John (died 1679), English stationer, tradesman
- Owen, Margaret (born 1742–died 1816), English home-maker
- Owen, Robert (born 1771–died 1858), Scottish socialist, reformer
- Owen, Reverend William (born c. 1618–died 1672), English churchman
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