Lives listing with initial: S
- Spencer, Charles, 3rd duke of Marlborough (born 1706–died 1758), English aristocrat, politician, army officer
- Spencer, George John, 2nd Earl Spencer (born 1758–died 1834), English politician, bibliophile, collector, academician
- Spencer, John (born 1630–died 1693), English churchman, university teacher, university administrator
- Spencer, John, 1st Earl Spencer (born 1734–died 1783), English aristocrat, patron, collector, politician, member of Parliament
- Spencer, John Charles, 3rd Earl Spencer (born 1782–died 1845), English politician, member of Parliament, sportsman, agriculturalist
- Spencer, Nicholas (died 1689), English merchant, politician, civil servant, governor
- Spens, George (flourished c. 1679), Scottish [unknown occupation]
- Spierin, Reverend George W. (flourished c. 1797), American churchman
- Spink, John (born 1729–died 1794), English draper, banker, accountant, philanthropist
- Spon, Doctor Jacob (born 1647–died 1685), French Huguenot, physician, antiquarian, archaeologist, author, historian, travel-writer, historian
- Spooner, Ephraim (born 1735–died 1818), American [unknown occupation]
- Spotsylvania County, a friend in (flourished 1789), American [unknown occupation]
- Spottiswoode, John [junior] (born 1711–died 1793), Scottish laird
- Spottiswoode, John (born 1741–died 1805), Scottish lawyer
- Spranger, Edward (flourished 1691–1704), English lawyer
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