Lives listing with initial: S
- Somers, John, 1st Baron Somers (born 1651–died 1716), English lawyer, politician, member of Parliament, civil servant, academician
- Somerville, Sir James, baronet (born c. 1698–died 1748), Irish gentleman, politician, member of Parliament
- Somerville, Mary [née Fairfax] (born 1780–died 1872), Scottish polymath, author, science-writer
- Sömmerring, Doctor Samuel Thomas von (born 1755–died 1830), German physician, anatomist, anthropologist, palaeontologist, inventor
- Somodevilla y Bengoechea, Zenón de, marqués de la Ensenada (born 1702–died 1781), Spanish aristocrat, statesman, civil servant, naval officer
- Sonnemans, Mattheus (flourished c. 1696), Dutch [unknown occupation]
- Sonnenberg, Gottfried von (flourished 1684–1685), German alchemist
- Sophia Albertina, princess of Sweden (born 1753–died 1829), Swedish aristocrat, princess
- Sophia Dorothea, queen consort of Prussia (born 1687–died 1757), German princess, consort
- Sophia Magdalena, queen consort of Sweden (born 1746–died 1813), Swedish consort
- Princess Sophia Matilda, of Gloucester (born 1773–died 1844), English aristocrat
- Sorbière, Samuel (born 1615–died 1670), French physician, astronomer, tutor, academician, executor
- Soret, Jean (born 1710), French lawyer, newspaper editor
- Soubise, Julius (born c. 1754–died 1795), Caribbean slave, socialite, tutor
- Souchu de Rennefort, René (flourished 1774–1789), French lawyer
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