Lives listing with initial: S
- Smith, Stanley M. (flourished 1879–1939), American soldier
- Smith, Sydney (born 1771–died 1845), English author, wit
- Smith, Thomas (born 1638–died 1710), English Orientalist, biographer, author
- Smith, Reverend Thomas (born 1638–died 1710), English Orientalist, schoolteacher, antiquarian
- Smith, Thomas (flourished 1794–1800), English shopkeeper, business agent
- Smith, William (born 1728–died 1814), American merchant, politician
- Smith, Major William (born 1751–died 1837), American colonist, plantation-owner, army officer, politician
- Smith, William (died 1753), Scottish guardian
- Smith, William (born 1755–died 1816), American merchant
- Smith, William (born 1756–died 1835), English politician, member of Parliament, Nonconformist
- Smith, William (born 1769–died 1839), English geologist, civil engineer, civil servant
- Smith, Lieutenant-colonel William Stephens (born 1755–died 1816), American revolutionary army officer, politician, civil servant
- Smithsby, Rabsy (born before 1660), English gentlewoman
- Smith-Stanley, Elizabeth, countess of Derby [née Farren] (born c. 1759–died 1829), Irish actress, aristocrat
- Smollett, Tobias (born 1721–died 1771), Scottish physician, surgeon, sailor, novelist, historian, travel-writer
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