Lives listing with initial: S
- Simon, Richard (born 1638–died 1712), French biblical scholar, theologian, author
- Simonde de Sismondi, Jean Charles Léonard (born 1773–died 1842), Swiss politician, economist, political philosopher, university teacher
- Simonds, Jonas (died c. 1816), American [unknown occupation]
- Simonnet de Lysle, M. — (flourished 1700–1738), French police officer
- Simpson, Doctor William (died 1680), English physician, alchemist
- Simson, Robert (born 1687–died 1768), Scottish university teacher, mathematician
- Sinclair, Sir John, 1st Baronet Sinclair of Ulbster (born 1754–died 1835), Scottish agriculturalist, politician, member of Parliament
- Sinner, Johann Rudolf (born 1730–died 1787), Swiss librarian, medievalist, archivist
- Sinsart, Benoît (born 1696–died 1776), French churchman, monk, Benedictine, theologian
- Sirejean Du Reclus, Jean Louis (born 1729–died 1815), French lawyer
- Sireuil, M. — (flourished c. 1754), French librettist
- Sirven, Jeanne (born after 1733), French home-maker
- Sirven, Pierre Paul (born 1709–died 1777), French notary, legal victim
- Sissous de Valmire, Pierre Louis (born 1740–died 1819), French lawyer, politician, author
- Six Nations, chiefs & representatives of the (appears in EE 1752–1762), Native American (Iroquois) tribal leader
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