Lives listing with initial: I
- Isaack, Reverend William (born 1650–died 1703), English churchman
- Iselin, Isaac (born 1728–died 1782), Swiss philosopher, scholar, academic
- Isham, Sir Justinian, 2nd baronet (born 1611–died 1675), English royalist, politician, member of Parliament, academician
- Isnard, Joseph (flourished 1661–1679), French notary
- Isnard, Maximin (born 1758–died 1825), French politician, author
- Isoard de Lisle, Jean Baptiste (born 1739–died 1816), French author, philosopher
- Issembourg Du Buisson d’Happoncourt, François Henri d’ (born c. 1672–died c. 1733), French army officer
- Ivernois, Charles Guillaume d’ (born 1732–died 1819), Swiss merchant, politician
- Ivernois, Sir Francis d’ (born 1757–died 1842), Swiss author, printer, lawyer, economist
- Ivernois, François Henri d’ (born 1722–died 1778), Swiss merchant, politician
- Ivernois, Guillaume Pierre d’ (born 1701–died 1775), Swiss notary, politician
- Ivernois, Marianne d’ [née Dehors] (born c. 1727–died 1796), Swiss home-maker
- Ivye, Ayliffe (flourished 1656–1661), English [unknown occupation]
- Izard, Ralph (born 1742–died 1804), American colonist, plantation-owner, diplomat, senator
- Izarn, Jacques Godefroy Charles Sébastien Xavier Jean Joseph, marquis de Valady (born 1766–died 1793), French aristocrat, army officer, politician, revolutionary
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