Lives listing with initial: C
- Clarke, Doctor Joseph (born 1758–died 1834), Irish physician, obstetrician
- Clarke, Mary [née Jepp] (born c. 1656–died c. 1705), English home-maker
- Clarke, Richard (flourished c. 1699), English [unknown occupation]
- Clarke, Samuel (born 1624–died 1669), English Orientalist, biblical scholar, theologian, author
- Clarke, Reverend Samuel (born 1626–died 1701), English churchman, Protestant, theologian, author
- Clarke, Samuel (flourished 1689–1704), English tailor, tradesman
- Clarke, Doctor William (born 1639–died 1684), English physician
- Clarke, William (flourished c. 1694), English [unknown occupation]
- Clarkson, Levinus (born 1740–died 1798), American merchant, speculator, slave trader
- Clason, Patrick (died 1811), Scottish schoolteacher, tutor
- Clauder, Doctor Gabriel (born 1633–died 1691), German physician, alchemist
- Clauseau, Jean (born c. 1751–died before 1845), French merchant
- Clavel de Brenles, Étiennette [née Chavannes] (born 1724–died 1780), French salon hostess
- Clavel de Brenles, Jacques Abram Elie Daniel (born 1717–died 1771), Swiss lawyer, legal author
- Clavering-Cowper, George Nassau, 3rd Earl Cowper (born 1738–died 1789), English aristocrat, politician, member of Parliament, art critic, collector, arts-patron, science patron
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